U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nsun-5 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [ Caenorhabditis elegans ]

    Gene ID: 175153, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nsun-5
    Official Full Name
    26S rRNA (cytosine-C(5))-methyltransferase nsun-5
    Primary source
    WormBase:WBGene00013151
    Locus tag
    CELE_Y53F4B.4
    See related
    AllianceGenome:WB:WBGene00013151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in several processes, including negative regulation of cellular response to heat; negative regulation of locomotion involved in locomotory behavior; and positive regulation of rRNA processing. Predicted to be active in nucleolus. Used to study Williams-Beuren syndrome. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nsun-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (14969617..14977005)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene tRNA N(3)-methylcytidine methyltransferase Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2016 May 11. PMID 27167997, Free PMC Article
    2. A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging. Adamla F, et al. Cell Physiol Biochem, 2019. PMID 30977983, Free PMC Article
    3. The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Heissenberger C, et al. Elife, 2020 Dec 8. PMID 33289480, Free PMC Article
    4. Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans. Navarro IC, et al. EMBO J, 2021 Mar 15. PMID 33283887, Free PMC Article
    5. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2015 Jan 30. PMID 25635753, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (cytosine-C5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    26S rRNA (cytosine-C(5))-methyltransferase nsun-5
    NP_001293548.1
    • Confirmed by transcript evidence
    NP_001366973.1
    • Confirmed by transcript evidence
    NP_001366974.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14969617..14977005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381672.1 → NP_001366973.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG0144
      Location:61 → 282
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    2. NM_001381671.1 → NP_001366974.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA7, Q9NAA8, U4PB26
      Conserved Domains (1) summary
      COG0144
      Location:139 → 436
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    3. NM_001306619.3 → NP_001293548.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB26
      Conserved Domains (1) summary
      COG0144
      Location:75 → 372
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NAA7.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools