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    hrg-1 Heme transporter hrg-1 [ Caenorhabditis elegans ]

    Gene ID: 180684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrg-1
    Official Full Name
    Heme transporter hrg-1
    Primary source
    WormBase:WBGene00019830
    Locus tag
    CELE_R02E12.6
    See related
    AllianceGenome:WB:WBGene00019830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane and lysosomal membrane. Is expressed in intestine. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrg-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (4008058..4016221, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Tektin Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene AcetylCholine Receptor Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haem transporter HRG-1 is essential in the barber's pole worm and an intervention target candidate. Yang Y, et al. PLoS Pathog, 2023 Jan. PMID 36716341, Free PMC Article
    2. Heme acquisition in the parasitic filarial nematode Brugia malayi. Luck AN, et al. FASEB J, 2016 Oct. PMID 27363426, Free PMC Article
    3. Heme metabolism and erythropoiesis. Chung J, et al. Curr Opin Hematol, 2012 May. PMID 22406824, Free PMC Article
    4. Topologically conserved residues direct heme transport in HRG-1-related proteins. Yuan X, et al. J Biol Chem, 2012 Feb 10. PMID 22174408, Free PMC Article
    5. A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans. Sinclair J, et al. J Biol Chem, 2010 Dec 10. PMID 20938051, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a model in which heme is translocated across membranes facilitated by conserved amino acids positioned on the exoplasmic, cytoplasmic, and transmembrane regions of HRG-1-related proteins.
      Title: Topologically conserved residues direct heme transport in HRG-1-related proteins.
    2. hrg-1 is a heme-responsive element that mediates transcriptional regulation in Caenorhabditis elegans
      Title: A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.
    3. identification of HRG-1 protein in C. elegans; these proteins are essential for haem homeostasis and normal development
      Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Heme transporter hrg-1
    NP_001370439.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4008058..4016221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383555.2 → NP_001370439.1  Heme transporter hrg-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21642
      Conserved Domains (1) summary
      pfam16954
      Location:107 → 161
      HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21642.2

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