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    bca-2 Carbonic anhydrase [ Caenorhabditis elegans ]

    Gene ID: 178484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bca-2
    Official Full Name
    Carbonic anhydrase
    Primary source
    WormBase:WBGene00013805
    Locus tag
    CELE_Y116A8C.28
    See related
    AllianceGenome:WB:WBGene00013805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bca-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (17096386..17100248, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2;DUF3800 domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Neighboring gene Branchpoint-bridging protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and biochemical analysis of the beta class carbonic anhydrases in Caenorhabditis elegans. Fasseas MK, et al. Mol Biol Rep, 2010 Jul. PMID 19816790
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Carbonic anhydrase
    NP_001255922.1
    • Partially confirmed by transcript evidence
    NP_001255923.1
    • Confirmed by transcript evidence
    NP_001299975.1
    • Confirmed by transcript evidence
    NP_001370216.1
    • Confirmed by transcript evidence
    NP_001379318.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17096386..17100248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392454.1 → NP_001379318.1  Carbonic anhydrase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I102
      Conserved Domains (1) summary
      cl00391
      Location:10 → 112
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    2. NM_001383263.2 → NP_001370216.1  Carbonic anhydrase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2YS41
      Conserved Domains (1) summary
      cl00391
      Location:10 → 232
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    3. NM_001268993.5 → NP_001255922.1  Carbonic anhydrase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQA9
      Conserved Domains (1) summary
      cl00391
      Location:10 → 277
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    4. NM_001313046.3 → NP_001299975.1  Carbonic anhydrase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARK9
      Conserved Domains (1) summary
      cl00391
      Location:1 → 173
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    5. NM_001268994.3 → NP_001255923.1  Carbonic anhydrase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQB0
    Nucleotide Protein
    Heading Accession and Version

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