hse-5 D-glucuronyl C5-epimerase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hse-5
Official Full Name: D-glucuronyl C5-epimerase
Primary source: WormBase:WBGene00002003
Locus tag: CELE_B0285.5
See related: AllianceGenome:WB:WBGene00002003
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable heparosan-N-sulfate-glucuronate 5-epimerase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification; regulation of cell migration; and regulation of growth. Predicted to be located in basement membrane; extracellular region; and plasma membrane. Predicted to be active in Golgi apparatus. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hse-5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (4345339..4350079)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genome-wide reverse genetic screen found the heparan sulfate-modifying enzyme hse-5 as one of the genes controlling TDP-43 neurotoxicity model in Caenorhabditis elegans.
Title: Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.
The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration.
Title: The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0285.4 (e-PCR)
- UniSTS:306713

B0285.5 (e-PCR)
- UniSTS:306714

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: D-glucuronyl C5-epimerase

NP_497876.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4345339..4350079

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065475.8 → NP_497876.2 D-glucuronyl C5-epimerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497876.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P46555, Q6Q8P8

Conserved Domains (1) summary

pfam06662
Location:407 → 606

C5-epim_C; D-glucuronyl C5-epimerase C-terminus