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    mec-14 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mec-14
    Official Full Name
    NADP-dependent oxidoreductase domain-containing protein
    Primary source
    WormBase:WBGene00003176
    Locus tag
    CELE_F37C12.12
    See related
    AllianceGenome:WB:WBGene00003176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mec-14 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7190189..7192992, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein eS21 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CDT1 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. Petersen CI, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15280551, Free PMC Article
    2. Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Chalfie M, et al. Science, 1989 Feb 24. PMID 2646709
    3. Genetic interactions affecting touch sensitivity in Caenorhabditis elegans. Gu G, et al. Proc Natl Acad Sci U S A, 1996 Jun 25. PMID 8692859, Free PMC Article
    4. The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans. Kostas SA, et al. Genes Dev, 2002 Jan 15. PMID 11799068, Free PMC Article
    5. Touch at the molecular level. Mechanosensation. García-Añoveros J, et al. Curr Biol, 1996 May 1. PMID 8805263

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein
    NP_498580.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7190189..7192992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066179.6 → NP_498580.2  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498580.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20127
      Conserved Domains (1) summary
      cd19163
      Location:83 → 376
      AKR_galDH; L-galactose dehydrogenase (L-galDH) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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