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    ccdc-55 Nuclear speckle splicing regulatory protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 175533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccdc-55
    Official Full Name
    Nuclear speckle splicing regulatory protein 1 homolog
    Primary source
    WormBase:WBGene00007627
    Locus tag
    CELE_C16C10.6
    See related
    AllianceGenome:WB:WBGene00007627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in inductive cell migration and nematode larval development. Located in cytoplasm and nucleus. Is expressed in several structures, including gonad; hypodermis; intestine; nervous system; and vulva. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ccdc-55 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (4166944..4168765, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene E3 ubiquitin ligase rnf-5;RING finger protein 5;RING-type E3 ubiquitin transferase Neighboring gene E3 ubiquitin ligase rnf-121 Neighboring gene putative histone deacetylase complex subunit SAP18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans. Kovacevic I, et al. Mech Dev, 2012 Jan-Feb. PMID 22285439, Free PMC Article
    2. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Garrido-Lecca A, et al. Mol Cell Biol, 2010 Aug. PMID 20498277, Free PMC Article
    3. Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans. Ferrier A, et al. PLoS One, 2011. PMID 22073173, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC-55 and the RNF genes act at least partially in parallel to promote termination of cell migration in the adult distal tip cells.
      Title: CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inductive cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear speckle splicing regulatory protein 1 homolog
    NP_497831.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4166944..4168765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065430.5 → NP_497831.1  Nuclear speckle splicing regulatory protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497831.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09252
      Conserved Domains (1) summary
      pfam09745
      Location:56 → 176
      DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09252.1

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