U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    B0252.3 Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3 [ Caenorhabditis elegans ]

    Gene ID: 174130, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    B0252.3
    Official Full Name
    Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3
    Primary source
    WormBase:WBGene00015088
    Locus tag
    CELE_B0252.3
    See related
    AllianceGenome:WB:WBGene00015088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to several human genes including SLC22A11 (solute carrier family 22 member 11); SLC22A14 (solute carrier family 22 member 14); and SLC22A24 (solute carrier family 22 member 24). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See B0252.3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6902846..6907757, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene putative 26S proteasome non-ATPase regulatory subunit 9 Neighboring gene Sphingomyelin phosphodiesterase 1 Neighboring gene Peptidyl-prolyl cis-trans isomerase 10 Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3
    NP_001021888.1
    • Partially confirmed by transcript evidence
    NP_001021889.1
    • Confirmed by transcript evidence
    NP_001367331.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6902846..6907757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381468.2 → NP_001367331.1  Putative transporter B0252.3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl28910
      Location:1 → 267
      MFS; Major Facilitator Superfamily

    2. NM_001026717.6 → NP_001021888.1  Putative transporter B0252.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021888.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10917, Q7YZF8
      Conserved Domains (1) summary
      cd06174
      Location:87 → 454
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_001026718.5 → NP_001021889.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JXY5
      Conserved Domains (2) summary
      PRK10077
      Location:186 → 246
      xylE; D-xylose transporter XylE; Provisional
      cd17317
      Location:53 → 434
      MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10917.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.