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    nmt-1 Glycylpeptide N-tetradecanoyltransferase;putative glycylpeptide N-tetradecanoyltransferase [ Caenorhabditis elegans ]

    Gene ID: 175861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nmt-1
    Official Full Name
    Glycylpeptide N-tetradecanoyltransferase;putative glycylpeptide N-tetradecanoyltransferase
    Primary source
    WormBase:WBGene00020549
    Locus tag
    CELE_T17E9.2
    See related
    AllianceGenome:WB:WBGene00020549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in protein localization to membrane. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; hypodermis; nervous system; pharynx; and reproductive system. Used to study muscular disease. Orthologous to human NMT1 (N-myristoyltransferase 1) and NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nmt-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (6114482..6116331, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase SULU Neighboring gene GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase Neighboring gene ABC transporter domain-containing protein Neighboring gene L domain-like protein;Leucine-rich repeat-containing protein 58

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. Galvin BD, et al. PLoS Negl Trop Dis, 2014 Sep. PMID 25188325, Free PMC Article
    2. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Fievet BT, et al. Nat Cell Biol, 2013 Jan. PMID 23242217, Free PMC Article
    3. Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis. Tang H, et al. Cell Rep, 2021 Aug 17. PMID 34407398, Free PMC Article
    4. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article
    5. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein myristoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glycylpeptide N-tetradecanoyltransferase;putative glycylpeptide N-tetradecanoyltransferase
    NP_498325.1
    • Partially confirmed by transcript evidence
    NP_498326.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6114482..6116331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065925.5 → NP_498326.1  putative glycylpeptide N-tetradecanoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498326.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46548
      Conserved Domains (3) summary
      COG5092
      Location:31 → 449
      NMT1; N-myristoyl transferase [Lipid metabolism]
      pfam01233
      Location:89 → 245
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:261 → 437
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    2. NM_065924.7 → NP_498325.1  Glycylpeptide N-tetradecanoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZN7
      Conserved Domains (3) summary
      COG5092
      Location:32 → 451
      NMT1; N-myristoyl transferase [Lipid metabolism]
      pfam01233
      Location:91 → 247
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:263 → 439
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RNA

    1. NR_132450.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46548.1

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