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    irk-2 Inward rectifier potassium channel irk-1 [ Caenorhabditis elegans ]

    Gene ID: 191695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    irk-2
    Official Full Name
    Inward rectifier potassium channel irk-1
    Primary source
    WormBase:WBGene00002150
    Locus tag
    CELE_M02A10.2
    See related
    AllianceGenome:WB:WBGene00002150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in intestine; pharyngeal-intestinal valve cell; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; glucose metabolism disease (multiple); heart conduction disease (multiple); heroin dependence; and long QT syndrome (multiple). Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12); KCNJ18 (potassium inwardly rectifying channel subfamily J member 18); and KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See irk-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (702971..714498, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NCAM (neural cell adhesion molecule) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase CBL Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced Ca(2+) transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway. Debnath A, et al. Front Neurosci, 2022. PMID 35937887, Free PMC Article
    2. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
    3. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inward rectifier potassium channel irk-1
    NP_001256976.2
    • Confirmed by transcript evidence
    NP_001256977.1
    • Confirmed by transcript evidence
    NP_001294850.1
    • Confirmed by transcript evidence
    NP_001317907.1
    • Confirmed by transcript evidence
    NP_001368348.1
    • Confirmed by transcript evidence
    NP_001368610.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      702971..714498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380896.1 → NP_001368348.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PN13
      Conserved Domains (2) summary
      pfam01007
      Location:33 → 173
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:180 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. NM_001270047.4 → NP_001256976.2  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256976.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT08
      Conserved Domains (1) summary
      pfam01007
      Location:33 → 355
      IRK; Inward rectifier potassium channel

    3. NM_001330888.3 → NP_001317907.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSR3

    4. NM_001380895.1 → NP_001368610.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSN6
      Conserved Domains (2) summary
      pfam01007
      Location:66 → 206
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:213 → 387
      IRK_C; Inward rectifier potassium channel C-terminal domain

    5. NM_001307921.4 → NP_001294850.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PSB4
      Conserved Domains (1) summary
      pfam01007
      Location:33 → 355
      IRK; Inward rectifier potassium channel

    6. NM_001270048.3 → NP_001256977.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYE6
      Conserved Domains (1) summary
      pfam01007
      Location:33 → 355
      IRK; Inward rectifier potassium channel
    Nucleotide Protein
    Heading Accession and Version

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