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    ptr-10 SSD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptr-10
    Official Full Name
    SSD domain-containing protein
    Primary source
    WormBase:WBGene00004224
    Locus tag
    CELE_F55F8.1
    See related
    AllianceGenome:WB:WBGene00004224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in molting cycle. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle membrane and plasma membrane. Is expressed in accessory cell. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptr-10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (5662284..5667068)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ribosome biogenesis protein WDR12 homolog Neighboring gene Mitochondrial fission factor Neighboring gene Protein-tyrosine-phosphatase Neighboring gene Secreted protein Neighboring gene Zinc transporter ZIP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. Oikonomou G, et al. PLoS Biol, 2011 Aug. PMID 21857800, Free PMC Article
    2. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Kuwabara PE, et al. Genes Dev, 2000 Aug 1. PMID 10921907, Free PMC Article
    3. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
    4. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
    5. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SSD domain-containing protein
    NP_001370752.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5662284..5667068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383129.2 → NP_001370752.1  SSD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91346
      Conserved Domains (1) summary
      cl25655
      Location:50 → 878
      Patched; Patched family
    Nucleotide Protein
    Heading Accession and Version

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