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    clu-1 Clustered mitochondria protein homolog [ Caenorhabditis elegans ]

    Gene ID: 176341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clu-1
    Official Full Name
    Clustered mitochondria protein homolog
    Primary source
    WormBase:WBGene00000550
    Locus tag
    CELE_F55H2.6
    See related
    AllianceGenome:WB:WBGene00000550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clu-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9516631..9521460, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative transmembrane ascorbate-dependent reductase CYB561 homolog Neighboring gene Uncharacterized protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Pre-mRNA-processing factor 40 homolog B;WW domain-containing protein ZK1098.1 Neighboring gene Small ribosomal subunit protein mS23 Neighboring gene Trafficking protein particle complex subunit 3 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria. Zhu Q, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207087, Free PMC Article
    2. The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution. Fields SD, et al. J Cell Sci, 1998 Jun. PMID 9601101
    3. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
    4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Clustered mitochondria protein homolog
    NP_499097.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9516631..9521460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066696.9 → NP_499097.1  Clustered mitochondria protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34466
      UniProtKB/TrEMBL
      Q9TYW0
      Conserved Domains (6) summary
      pfam05303
      Location:229 → 302
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:747 → 914
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:355 → 578
      CLU; Clustered mitochondria
      pfam13374
      Location:1119 → 1155
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1069 → 1147
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:69 → 141
      CLU_N; Mitochondrial function, CLU-N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34466.1

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