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    asp-12 Peptidase A1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179210, updated on 9-Dec-2024

    Summary

    Official Symbol
    asp-12
    Official Full Name
    Peptidase A1 domain-containing protein
    Primary source
    WormBase:WBGene00017678
    Locus tag
    CELE_F21F8.4
    See related
    AllianceGenome:WB:WBGene00017678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in innate immune response. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See asp-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (8270643..8272056)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Aspartic protease 6 Neighboring gene Peptidase A1 domain-containing protein Neighboring gene pseudo

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response HEP PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Peptidase A1 domain-containing protein
    NP_505134.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8270643..8272056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072733.7NP_505134.1  Peptidase A1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01531
      Conserved Domains (1) summary
      pfam00026
      Location:72388
      Asp; Eukaryotic aspartyl protease