egl-27 Egg-laying defective protein 27;GATA-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-27
Official Full Name: Egg-laying defective protein 27;GATA-type domain-containing protein
Primary source: WormBase:WBGene00001194
Locus tag: CELE_C04A2.3
See related: AllianceGenome:WB:WBGene00001194
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including anal region; epithelial system; gonadal primordium; head; and tail. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to several human genes including RERE (arginine-glutamic acid dipeptide repeats). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-27 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (6835008..6847906)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the GATA transcription factor EGL-27 co-regulates DAF-16 target genes in response to DNA damage and together with DAF-16 promotes developmental growth.
Title: DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
These results identify egl-27 as a novel factor that links stress and aging pathways.
Title: The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04A2.2 (e-PCR)
- UniSTS:308916

C04A2.3 (e-PCR)
- UniSTS:319986

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transdifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Egg-laying defective protein 27;GATA-type domain-containing protein

NP_001263660.1

Confirmed by transcript evidence

NP_001300494.1

Confirmed by transcript evidence

NP_001300495.1

Confirmed by transcript evidence

NP_001300497.1

Confirmed by transcript evidence

NP_001300498.1

Confirmed by transcript evidence

NP_001300499.1

Confirmed by transcript evidence

NP_001300500.1

Confirmed by transcript evidence

NP_001300501.1

Partially confirmed by transcript evidence

NP_001300504.1

Confirmed by transcript evidence

NP_001367420.1

Confirmed by transcript evidence

NP_001368508.1

Confirmed by transcript evidence

NP_001368509.1

Confirmed by transcript evidence

NP_001368510.1

Confirmed by transcript evidence

NP_001368511.1

Confirmed by transcript evidence

NP_001370943.1

Partially confirmed by transcript evidence

NP_001379615.1

Confirmed by transcript evidence

NP_001380178.1

Confirmed by transcript evidence

NP_741012.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6835008..6847906

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381463.1 → NP_001367420.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

cd11661
Location:192 → 237

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:290 → 339

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cl02608
Location:1 → 106

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

pfam01448
Location:85 → 133

ELM2; ELM2 domain
NM_171011.4 → NP_741012.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741012.1

Status: REVIEWED

UniProtKB/Swiss-Prot

J7RNK9, Q09228, Q09229, Q86LT4, Q8MQF3, Q9XYD0

Conserved Domains (6) summary

smart00717
Location:335 → 382

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:336 → 381

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:434 → 483

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:438 → 488

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:86 → 247

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:226 → 274

ELM2; ELM2 domain
NM_001393107.1 → NP_001379615.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED
NM_001313565.3 → NP_001300494.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATV0

Conserved Domains (6) summary

smart00717
Location:335 → 382

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:336 → 381

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:434 → 483

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:438 → 488

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:86 → 247

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:226 → 274

ELM2; ELM2 domain
NM_001313566.3 → NP_001300495.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AQW8

Conserved Domains (6) summary

smart00717
Location:332 → 379

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:333 → 378

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:431 → 480

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:435 → 485

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:86 → 247

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:226 → 274

ELM2; ELM2 domain
NM_001381461.1 → NP_001368508.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUG2

Conserved Domains (4) summary

cd11661
Location:333 → 378

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:431 → 480

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:86 → 247

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:226 → 274

ELM2; ELM2 domain
NM_001313568.3 → NP_001300497.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWS4

Conserved Domains (6) summary

smart00717
Location:301 → 348

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:302 → 347

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:400 → 449

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:404 → 454

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:52 → 213

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:192 → 240

ELM2; ELM2 domain
NM_001313569.3 → NP_001300498.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARG1

Conserved Domains (6) summary

smart00717
Location:301 → 348

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:302 → 347

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:400 → 449

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:404 → 454

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:52 → 213

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:192 → 240

ELM2; ELM2 domain
NM_001313570.3 → NP_001300499.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATV3

Conserved Domains (6) summary

smart00717
Location:298 → 345

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:299 → 344

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:397 → 446

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:401 → 451

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:52 → 213

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:192 → 240

ELM2; ELM2 domain
NM_001313571.3 → NP_001300500.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AQX3

Conserved Domains (6) summary

smart00717
Location:298 → 345

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:299 → 344

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:397 → 446

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:401 → 451

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:52 → 213

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:192 → 240

ELM2; ELM2 domain
NM_001393106.1 → NP_001380178.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWS8

Conserved Domains (4) summary

cd11661
Location:195 → 240

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:293 → 342

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:85 → 133

ELM2; ELM2 domain

cl02608
Location:1 → 106

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
NM_001381462.1 → NP_001368509.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARG6

Conserved Domains (4) summary

cd11661
Location:195 → 240

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:293 → 342

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:85 → 133

ELM2; ELM2 domain

cl02608
Location:1 → 106

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
NM_001313575.3 → NP_001300504.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATV6

Conserved Domains (6) summary

smart00717
Location:191 → 238

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:192 → 237

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:290 → 339

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:294 → 344

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam01448
Location:85 → 133

ELM2; ELM2 domain

cl02608
Location:1 → 106

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
NM_001383872.2 → NP_001370943.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AQX8

Conserved Domains (2) summary

cd11661
Location:98 → 143

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:196 → 245

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
NM_001381464.1 → NP_001368510.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUH3

Conserved Domains (2) summary

cd11661
Location:98 → 143

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:196 → 245

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
NM_001276731.3 → NP_001263660.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09228
NM_001381465.1 → NP_001368511.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWT1

Conserved Domains (2) summary

cd11661
Location:95 → 140

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:193 → 242

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
NM_001313572.3 → NP_001300501.1 Egg-laying defective protein 27 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUG7