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    svh-5 ETS domain-containing protein;Ets-domain protein [ Caenorhabditis elegans ]

    Gene ID: 181627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    svh-5
    Official Full Name
    ETS domain-containing protein;Ets-domain protein
    Primary source
    WormBase:WBGene00006462
    Locus tag
    CELE_C33A11.4
    See related
    AllianceGenome:WB:WBGene00006462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in excretory system; intestine; nervous system; and rectal epithelium. Orthologous to human ELF3 (E74 like ETS transcription factor 3); ELF5 (E74 like ETS transcription factor 5); and EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See svh-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (15369974..15377824, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ANK repeat-containing protein nipk-1 Neighboring gene ncRNA Neighboring gene Aa_trans domain-containing protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Roh HC, et al. Nucleic Acids Res, 2015 Jan. PMID 25552416, Free PMC Article
    2. Gene regulatory logic of dopamine neuron differentiation. Flames N, et al. Nature, 2009 Apr 16. PMID 19287374, Free PMC Article
    3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS domain-containing protein;Ets-domain protein
    NP_001257261.1
    • Confirmed by transcript evidence
    NP_001379521.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15369974..15377824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270332.3 → NP_001257261.1  Ets-domain protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC57
      Conserved Domains (2) summary
      cd08757
      Location:135 → 203
      SAM_PNT_ESE; Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators
      smart00413
      Location:393 → 485
      ETS; erythroblast transformation specific domain

    2. NM_001392898.1 → NP_001379521.1  ETS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHC2
      Conserved Domains (2) summary
      cd08757
      Location:43 → 111
      SAM_PNT_ESE; Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators
      smart00413
      Location:301 → 393
      ETS; erythroblast transformation specific domain
    Nucleotide Protein
    Heading Accession and Version

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