swsn-9 Bromo domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: swsn-9
Official Full Name: Bromo domain-containing protein
Primary source: WormBase:WBGene00007256
Locus tag: CELE_C01H6.7
See related: AllianceGenome:WB:WBGene00007256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in intestine; muscle cell; pharynx; and somatic gonad. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See swsn-9 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (7224808..7227763)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
Title: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01H6.7 (e-PCR)
- UniSTS:307204

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Bromo domain-containing protein

NP_001366778.1

Confirmed by transcript evidence

NP_001367154.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7224808..7227763

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380647.2 → NP_001366778.1 Bromo domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17581

Conserved Domains (2) summary

pfam12024
Location:288 → 478

DUF3512; Domain of unknown function (DUF3512)

cl02556
Location:151 → 240

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001380648.1 → NP_001367154.1 Bromo domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A5JYT2

Conserved Domains (2) summary

pfam12024
Location:288 → 478

DUF3512; Domain of unknown function (DUF3512)

cl02556
Location:151 → 240

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.