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    kmo-2 FAD-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kmo-2
    Official Full Name
    FAD-binding domain-containing protein
    Primary source
    WormBase:WBGene00011088
    Locus tag
    CELE_R07B7.4
    See related
    AllianceGenome:WB:WBGene00011088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kynurenine 3-monooxygenase activity. Predicted to be involved in kynurenine metabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kmo-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (12065965..12067957, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Chloride channel protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene Kynurenine 3-monooxygenase Neighboring gene Nucleotid_trans domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in kynurenine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAD-binding domain-containing protein
    NP_001129902.1
    • Confirmed by transcript evidence
    NP_001359579.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12065965..12067957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373128.2 → NP_001359579.1  FAD-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21794
      Conserved Domains (1) summary
      COG0654
      Location:9 → 304
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

    2. NM_001136430.1 → NP_001129902.1  FAD-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5BM30
      Conserved Domains (1) summary
      COG0654
      Location:1 → 344
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version

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