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    lag-2 Protein lag-2 [ Caenorhabditis elegans ]

    Gene ID: 178755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lag-2
    Official Full Name
    Protein lag-2
    Primary source
    WormBase:WBGene00002246
    Locus tag
    CELE_Y73C8B.4
    See related
    AllianceGenome:WB:WBGene00002246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Notch binding activity. Involved in several processes, including maintenance of dauer; positive regulation of stem cell proliferation; and regulation of basement membrane organization. Located in cell projection membrane and neuronal cell body membrane. Is expressed in several structures, including CAN; distal tip cell; head neurons; somatic gonad precursor; and vulval cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lag-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (3188343..3190115)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modelling the Caenorhabditis elegans gonad over developmental time using the Distal Tip Cell marker lag-2p::gfp. Crook M, et al. MicroPubl Biol, 2022. PMID 36060032, Free PMC Article
    2. A DTC niche plexus surrounds the germline stem cell pool in Caenorhabditis elegans. Byrd DT, et al. PLoS One, 2014. PMID 24586318, Free PMC Article
    3. Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina. Margalit A, et al. Proc Natl Acad Sci U S A, 2005 Mar 1. PMID 15728376, Free PMC Article
    4. Higher-order epistasis shapes natural variation in germ stem cell niche activity. Fausett SR, et al. Nat Commun, 2023 May 17. PMID 37198172, Free PMC Article
    5. An in vivo toolkit to visualize endogenous LAG-2/Delta and LIN-12/Notch signaling in C. elegans. Medwig-Kinney TN, et al. MicroPubl Biol, 2022. PMID 35966395, Free PMC Article

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of dauer IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lag-2
    NP_503877.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3188343..3190115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071476.3 → NP_503877.1  Protein lag-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45442
      Conserved Domains (1) summary
      smart00051
      Location:103 → 166
      DSL; delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45442.1

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