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    pll-1 Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

    Gene ID: 187273, updated on 27-Dec-2024

    Summary

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    Official Symbol
    pll-1
    Official Full Name
    Phosphoinositide phospholipase C
    Primary source
    WormBase:WBGene00004045
    Locus tag
    CELE_K10F12.3
    See related
    AllianceGenome:WB:WBGene00004045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in AIYL and AIYR. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)) and PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pll-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    21
    Sequence:
    Chromosome: III; NC_003281.10 (365949..377570)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene GST N-terminal domain-containing protein;Glutathione-dependent dehydroascorbate reductase Neighboring gene Ovule protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males. Gower NJ, et al. Mol Biol Cell, 2005 Sep. PMID 15958491, Free PMC Article
    2. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article
    3. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Yin X, et al. Mol Biol Cell, 2004 Aug. PMID 15194811, Free PMC Article
    4. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Ziegler K, et al. Cell Host Microbe, 2009 Apr 23. PMID 19380113
    5. Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Wenick AS, et al. Dev Cell, 2004 Jun. PMID 15177025

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphoinositide phospholipase C
    NP_741067.1
    • Confirmed by transcript evidence
    NP_741068.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      365949..377570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171059.6 → NP_741067.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA76
      Conserved Domains (5) summary
      cd00275
      Location:680 → 808
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08558
      Location:357 → 653
      PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
      PLN02228
      Location:268 → 810
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:75 → 184
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      pfam09279
      Location:276 → 356
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_171060.5 → NP_741068.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA75
      Conserved Domains (5) summary
      cd00275
      Location:687 → 815
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08558
      Location:364 → 660
      PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
      PLN02228
      Location:275 → 817
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:82 → 191
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      pfam09279
      Location:283 → 363
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    Nucleotide Protein
    Heading Accession and Version

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