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    rsf-1 Ras association domain-containing protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 174728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsf-1
    Official Full Name
    Ras association domain-containing protein 1 homolog
    Primary source
    WormBase:WBGene00011995
    Locus tag
    CELE_T24F1.3
    See related
    AllianceGenome:WB:WBGene00011995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in several processes, including chromosome condensation; positive regulation of response to oxidative stress; and regulation of vulval development. Predicted to be located in cytoplasm and microtubule. Is expressed in neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including RASSF1 (Ras association domain family member 1) and RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsf-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (11306399..11311942)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene GTP-binding protein Neighboring gene Transmembrane protein 201 homolog Neighboring gene ncRNA Neighboring gene Small integral membrane protein 36 Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response. Takenaka M, et al. Genes Cells, 2013 Mar. PMID 23294242
    2. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Iwasa H, et al. Exp Cell Res, 2013 Feb 1. PMID 23103556
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T24F1.3/rasf-1 directly interacts with rab-39.
      Title: C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
    2. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. [
      Title: Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras association domain-containing protein 1 homolog
    NP_001022361.1
    • Confirmed by transcript evidence
    NP_001370200.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11306399..11311942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027190.5 → NP_001022361.1  Ras association domain-containing protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22744, Q58AA9
      Conserved Domains (3) summary
      cd01778
      Location:358 → 494
      RA_RASSF1_like; Ras-associating (RA) domain found in Ras-association domain family members, RASSF1, RASSF3, and RASSF5
      pfam16517
      Location:504 → 542
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cd20885
      Location:163 → 215
      C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins

    2. NM_001383950.2 → NP_001370200.1  Ras association domain-containing protein 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd01778
      Location:297 → 433
      RA_RASSF1_like; Ras-associating (RA) domain found in Ras-association domain family members, RASSF1, RASSF3, and RASSF5
      pfam16517
      Location:443 → 481
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cd20885
      Location:102 → 154
      C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22744.1

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