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    acs-5 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

    Gene ID: 176785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-5
    Official Full Name
    Long-chain-fatty-acid--CoA ligase
    Primary source
    WormBase:WBGene00013575
    Locus tag
    CELE_Y76A2B.3
    See related
    AllianceGenome:WB:WBGene00013575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (13540139..13543534, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. Ruiz M, et al. Elife, 2019 Nov 26. PMID 31769755, Free PMC Article
    2. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Srinivasan S, et al. Cell Metab, 2008 Jun. PMID 18522834, Free PMC Article
    3. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
    4. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
    5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Long-chain-fatty-acid--CoA ligase
    NP_499799.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13540139..13543534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067398.7 → NP_499799.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWD1
      Conserved Domains (2) summary
      PLN02736
      Location:65 → 685
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:101 → 681
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein
    Heading Accession and Version

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