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    T21D12.12 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T21D12.12
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00020651
    Locus tag
    CELE_T21D12.12
    See related
    AllianceGenome:WB:WBGene00020651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T21D12.12 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (266448..268322)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WW domain-containing protein Neighboring gene Paralyzed arrest at two-fold protein 6 Neighboring gene Serine/threonine-protein kinase DDB_G0282963 Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_499892.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      266448..268322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067491.7 → NP_499892.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16784
      Conserved Domains (2) summary
      cd00109
      Location:127 → 183
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:23 → 77
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein
    Heading Accession and Version

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