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    dhs-7 NAD(P)-binding protein [ Caenorhabditis elegans ]

    Gene ID: 174183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-7
    Official Full Name
    NAD(P)-binding protein
    Primary source
    WormBase:WBGene00000971
    Locus tag
    CELE_E04F6.7
    See related
    AllianceGenome:WB:WBGene00000971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in regulation of reactive oxygen species metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7206990..7208460, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class D (Delta) Neighboring gene Serpentine Receptor, class D (delta) Neighboring gene Serpentine receptor class delta-59 Neighboring gene DeHydrogenases, Short chain Neighboring gene Cuticle protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Monaghan RM, et al. Nat Cell Biol, 2015 Jun. PMID 25961505, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding protein
    NP_495500.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7206990..7208460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063099.5 → NP_495500.1  NAD(P)-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19062
      Conserved Domains (2) summary
      cd05327
      Location:28 → 307
      retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
      PRK06197
      Location:28 → 313
      PRK06197; short chain dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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