hip-1 STI1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hip-1
Official Full Name: STI1 domain-containing protein
Primary source: WormBase:WBGene00011735
Locus tag: CELE_T12D8.8
See related: AllianceGenome:WB:WBGene00011735
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Hsp70 protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in germ line; head; hypodermis; intestine; and tail. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein) and ST13P5 (ST13, Hsp70 interacting protein pseudogene 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hip-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (13614696..13622226, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T12D8.8 (e-PCR)
- UniSTS:322316

T12D8.9 (e-PCR)
- UniSTS:306533

T12D8.6 (e-PCR)
- UniSTS:317052

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in sarcomere	HDA more info	PubMed
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: STI1 domain-containing protein

NP_499811.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13614696..13622226 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067410.7 → NP_499811.1 STI1 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499811.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE04

Conserved Domains (4) summary

PLN03088
Location:115 → 226

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:148 → 178

TPR; TPR repeat [structural motif]

pfam17830
Location:320 → 368

STI1; STI1 domain

pfam18253
Location:2 → 41

HipN; Hsp70-interacting protein N N-terminal domain