adsl-1 Adenylosuccinate lyase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adsl-1
Official Full Name: Adenylosuccinate lyase
Primary source: WormBase:WBGene00011064
Locus tag: CELE_R06C7.5
See related: AllianceGenome:WB:WBGene00011064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be active in cytosol. Used to study adenylosuccinase lyase deficiency. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adsl-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (7246904..7248689, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans.
Title: Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans.
adsl-1 is required for developmental timing, germline stem cell maintenance and muscle integrity.
Title: Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06C7.7 (e-PCR)
- UniSTS:312067

R06C7.5 (e-PCR)
- UniSTS:321618

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	IEA Inferred from Electronic Annotation more info
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Adenylosuccinate lyase

NP_001367034.1

Confirmed by transcript evidence

NP_492049.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7246904..7248689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380665.2 → NP_001367034.1 Adenylosuccinate lyase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl00013
Location:11 → 352

Lyase_I_like; Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions
NM_059648.7 → NP_492049.1 Adenylosuccinate lyase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492049.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21774, Q8I4G8

Conserved Domains (2) summary

cd03302
Location:11 → 446

Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2

TIGR00928
Location:11 → 454

purB; adenylosuccinate lyase