pigk-1 Putative GPI-anchor transamidase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pigk-1
Official Full Name: Putative GPI-anchor transamidase
Primary source: WormBase:WBGene00011482
Locus tag: CELE_T05E11.6
See related: AllianceGenome:WB:WBGene00011482
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pigk-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11108085..11110018, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05E11.1 (e-PCR)
- UniSTS:318422

T05E11.6 (e-PCR)
- UniSTS:307930

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GPI-anchor transamidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GPI-anchor transamidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative GPI-anchor transamidase

NP_001366758.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11108085..11110018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380460.2 → NP_001366758.1 Putative GPI-anchor transamidase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P49048

Conserved Domains (1) summary

cl00042
Location:35 → 302

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...