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    tsp-20 Tetraspanin [ Caenorhabditis elegans ]

    Gene ID: 181376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsp-20
    Official Full Name
    Tetraspanin
    Primary source
    WormBase:WBGene00006646
    Locus tag
    CELE_B0198.1
    See related
    AllianceGenome:WB:WBGene00006646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to several human genes including CD151 (CD151 molecule (Raph blood group)); CD37 (CD37 molecule); and TSPAN16 (tetraspanin 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsp-20 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (12031592..12034037, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane protein 196 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans. Yang B, et al. Genes Dev, 2020 Sep 1. PMID 32820039, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetraspanin
    NP_510014.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12031592..12034037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077613.7 → NP_510014.1  Tetraspanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17441
      Conserved Domains (2) summary
      cd03155
      Location:118 → 231
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:24 → 258
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version

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