kvs-4 BTB domain-containing protein;putative voltage-gated potassium channel subunit kvs-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kvs-4
Official Full Name: BTB domain-containing protein;putative voltage-gated potassium channel subunit kvs-4
Primary source: WormBase:WBGene00012967
Locus tag: CELE_Y48A6B.6
See related: AllianceGenome:WB:WBGene00012967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable potassium channel regulator activity. Involved in long-term memory. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; and epilepsy. Orthologous to several human genes including KCNF1 (potassium voltage-gated channel modifier subfamily F member 1) and KCNS2 (potassium voltage-gated channel modifier subfamily S member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kvs-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (11012564..11025293)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest UNC-101/AP-1 mu1 subunit exhibits a novel bipartite sorting signal within KVS-4/Kv2.1 consisting of C-terminal EQMIL and N-terminal WNIIE motifs; such sorting signals appear to account for somatodendritic distribution of KVS-4/Kv2.1.
Title: A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48A6B.6 (e-PCR)
- UniSTS:313325

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB domain-containing protein;putative voltage-gated potassium channel subunit kvs-4

NP_001022888.1

Partially confirmed by transcript evidence

NP_001367099.1

Confirmed by transcript evidence

NP_001408256.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11012564..11025293

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001421331.1 → NP_001408256.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7R9SUL9
NM_001379921.2 → NP_001367099.1 putative voltage-gated potassium channel subunit kvs-4 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd18317
Location:121 → 208

BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels

pfam00520
Location:265 → 513

Ion_trans; Ion transport protein
NM_001027717.3 → NP_001022888.1 putative voltage-gated potassium channel subunit kvs-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022888.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6EUU0, Q9XXD1

Conserved Domains (2) summary

pfam00520
Location:229 → 477

Ion_trans; Ion transport protein

cl02518
Location:85 → 182

BTB; BTB/POZ domain