T26C12.1 2-hydroxyacyl-CoA lyase 2 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: T26C12.1
Official Full Name: 2-hydroxyacyl-CoA lyase 2
Primary source: WormBase:WBGene00020831
Locus tag: CELE_T26C12.1
See related: AllianceGenome:WB:WBGene00020831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in L-valine biosynthetic process; fatty acid alpha-oxidation; and isoleucine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Is expressed in body wall musculature; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human ILVBL (ilvB acetolactate synthase like). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See T26C12.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (3258910..3263489)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T26C12.1 (e-PCR)
- UniSTS:311021

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetolactate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid alpha-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: 2-hydroxyacyl-CoA lyase 2

NP_500306.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3258910..3263489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067905.6 → NP_500306.1 2-hydroxyacyl-CoA lyase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500306.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61856

Conserved Domains (4) summary

cd07035
Location:60 → 214

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK05858
Location:52 → 632

PRK05858; hypothetical protein; Provisional

cd02004
Location:454 → 628

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:277 → 408

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain