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    dpf-1 Dipeptidyl peptidase family member 1 [ Caenorhabditis elegans ]

    Gene ID: 180042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpf-1
    Official Full Name
    Dipeptidyl peptidase family member 1
    Primary source
    WormBase:WBGene00001054
    Locus tag
    CELE_T23F1.7
    See related
    AllianceGenome:WB:WBGene00001054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; asthma; autosomal dominant intellectual developmental disorder 33; motor neuron disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpf-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (15471329..15476124)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase;Nucleotid_trans domain-containing protein;Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-150 Neighboring gene tRNA-Ala Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dipeptidyl peptidase family member 1
    NP_001256667.1
    • Confirmed by transcript evidence
    NP_506850.1
    • Confirmed by transcript evidence
    NP_506851.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15471329..15476124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074449.6 → NP_506850.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18119, Q7JKY3
      Conserved Domains (3) summary
      COG1506
      Location:524 → 798
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:615 → 795
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:182 → 507
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_074450.7 → NP_506851.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JKY3
      Conserved Domains (3) summary
      COG1506
      Location:504 → 778
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:595 → 775
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:162 → 487
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001269738.3 → NP_001256667.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6R8X0
      Conserved Domains (3) summary
      COG1506
      Location:464 → 738
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:555 → 735
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:122 → 447
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JKY3.1

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