aptf-1 Transcription factor aptf-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aptf-1
Official Full Name: Transcription factor aptf-1
Primary source: WormBase:WBGene00019424
Locus tag: CELE_K06A1.1
See related: AllianceGenome:WB:WBGene00019424
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sleep. Predicted to be active in nucleus. Is expressed in head neurons and pharyngeal neurons. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and patent ductus arteriosus. Orthologous to several human genes including TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aptf-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (6454971..6456546)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aptf-1 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.
Title: An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K06A1.1 (e-PCR)
- UniSTS:311427

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor aptf-1

NP_495300.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6454971..6456546

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062899.4 → NP_495300.2 Transcription factor aptf-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495300.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09585

Conserved Domains (1) summary

pfam03299
Location:152 → 355

TF_AP-2; Transcription factor AP-2