dbr-1 Lariat debranching enzyme [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dbr-1
Official Full Name: Lariat debranching enzyme
Primary source: WormBase:WBGene00000937
Locus tag: CELE_C55B7.8
See related: AllianceGenome:WB:WBGene00000937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dbr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (6490716..6492727, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C55B7.9 (e-PCR)
- UniSTS:316445

C55B7.8 (e-PCR)
- UniSTS:309432

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA lariat debranching enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA lariat debranching enzyme activity	IEA Inferred from Electronic Annotation more info
enables RNA lariat debranching enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing, via transesterification reactions	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Lariat debranching enzyme

NP_491868.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6490716..6492727 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059467.6 → NP_491868.2 Lariat debranching enzyme [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491868.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P90972, Q966M6

Conserved Domains (3) summary

cd00844
Location:43 → 311

MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain

pfam00149
Location:41 → 277

Metallophos; Calcineurin-like phosphoesterase

pfam05011
Location:293 → 428

DBR1; Lariat debranching enzyme, C-terminal domain