ckr-1 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ckr-1
Official Full Name: G-protein coupled receptors family 1 profile domain-containing protein
Primary source: WormBase:WBGene00020712
Locus tag: CELE_T23B3.4
See related: AllianceGenome:WB:WBGene00020712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neuropeptide receptor activity. Involved in determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in obesity and pancreatic cancer. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ckr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (6687349..6691671, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.
Title: A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23B3.4 (e-PCR)
- UniSTS:315063

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptors family 1 profile domain-containing protein

NP_491918.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6687349..6691671 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059517.4 → NP_491918.3 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491918.3

Status: REVIEWED

UniProtKB/TrEMBL

P91487

Conserved Domains (1) summary

cd14993
Location:30 → 375

7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors