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    skih-2 Helicase SKI2W [ Caenorhabditis elegans ]

    Gene ID: 178017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skih-2
    Official Full Name
    Helicase SKI2W
    Primary source
    WormBase:WBGene00008502
    Locus tag
    CELE_F01G4.3
    See related
    AllianceGenome:WB:WBGene00008502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIC2 (SKI2 subunit of superkiller complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skih-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (11135566..11142364, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2 Neighboring gene ncRNA Neighboring gene CNH domain-containing protein Neighboring gene PMT_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonsense mRNA suppression via nonstop decay. Arribere JA, et al. Elife, 2018 Jan 8. PMID 29309033, Free PMC Article
    2. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Helicase SKI2W
    NP_502084.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11135566..11142364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069683.5 → NP_502084.2  Helicase SKI2W [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502084.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19103
      Conserved Domains (5) summary
      smart00490
      Location:612 → 704
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:287 → 472
      DEXDc; DEAD-like helicases superfamily
      pfam00270
      Location:295 → 440
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:1093 → 1257
      DSHCT; DSHCT (NUC185) domain
      cl00354
      Location:1017 → 1065
      KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
    Nucleotide Protein
    Heading Accession and Version

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