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    Y48A6B.9 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y48A6B.9
    Official Full Name
    Enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Primary source
    WormBase:WBGene00012970
    Locus tag
    CELE_Y48A6B.9
    See related
    AllianceGenome:WB:WBGene00012970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y48A6B.9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (11033172..11036088)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Wsv161 Neighboring gene NR LBD domain-containing protein Neighboring gene Protein lilliputian;Suppressor of PAr-Two defect Neighboring gene Regulator of spindle assembly protein 2 Neighboring gene ncRNA Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Enoyl-[acyl-carrier-protein] reductase, mitochondrial
    NP_001255097.1
    • Confirmed by transcript evidence
    NP_001255098.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11033172..11036088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268168.3 → NP_001255097.1  Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXC8
      Conserved Domains (2) summary
      cd08290
      Location:7 → 337
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:8 → 337
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    2. NM_001268169.4 → NP_001255098.1  Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5Q6
      Conserved Domains (1) summary
      cl16912
      Location:1 → 86
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXC8.1

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