U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cpr-5 Cathepsin B-like cysteine proteinase 5 [ Caenorhabditis elegans ]

    Gene ID: 178612, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cpr-5
    Official Full Name
    Cathepsin B-like cysteine proteinase 5
    Primary source
    WormBase:WBGene00000785
    Locus tag
    CELE_W07B8.5
    See related
    AllianceGenome:WB:WBGene00000785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cpr-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (1132598..1134036, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Expressed conserved protein;PB1 domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans. Redmond DL, et al. Mol Biochem Parasitol, 2001 Jan 15. PMID 11166393
    2. Simple Evaluation of Listeria monocytogenes Pathogenesis Using Caenorhabditis elegans Animal Model. Yang KH, et al. Food Sci Anim Resour, 2019 Feb. PMID 30882077, Free PMC Article
    3. Insights into the Neuroprotective Potential of Epicatechin: Effects against Aβ-Induced Toxicity in Caenorhabditis elegans. Ayuda-Durán B, et al. Antioxidants (Basel), 2024 Jan 8. PMID 38247503, Free PMC Article
    4. Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. Larminie CG, et al. DNA Cell Biol, 1996 Jan. PMID 8561899
    5. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cathepsin B-like cysteine proteinase 5
    NP_503383.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1132598..1134036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070982.7 → NP_503383.1  Cathepsin B-like cysteine proteinase 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43509
      Conserved Domains (2) summary
      cd02620
      Location:83 → 336
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:30 → 63
      Propeptide_C1; Peptidase family C1 propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43509.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools