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    frm-3 FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 186110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frm-3
    Official Full Name
    FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1
    Primary source
    WormBase:WBGene00001490
    Locus tag
    CELE_H05G16.1
    See related
    AllianceGenome:WB:WBGene00001490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GABA receptor binding activity. Involved in gamma-aminobutyric acid receptor clustering. Predicted to be located in adherens junction and plasma membrane. Is expressed in body wall musculature and dorsal nerve cord. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to several human genes including FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See frm-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    20
    Sequence:
    Chromosome: X; NC_003284.9 (11572505..11585126)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bicarbonate transporter-like transmembrane domain-containing protein Neighboring gene PID domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission. Li L, et al. PLoS Genet, 2022 Oct. PMID 36279278, Free PMC Article
    2. FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome. Jiang L, et al. Invest Ophthalmol Vis Sci, 2020 May 11. PMID 32446246, Free PMC Article
    3. The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA(A) receptors. Zhou X, et al. Nat Commun, 2020 May 29. PMID 32471987, Free PMC Article
    4. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. Tong XJ, et al. Elife, 2015 Nov 17. PMID 26575289, Free PMC Article
    5. UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs. Hao Y, et al. Nat Commun, 2023 Mar 15. PMID 36918518, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GABA receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid receptor clustering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1
    NP_001338849.1
    • Confirmed by transcript evidence
    NP_001361874.1
    • Confirmed by transcript evidence
    NP_509935.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11572505..11585126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351892.5 → NP_001338849.1  Moesin/ezrin/radixin homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBN3
      Conserved Domains (6) summary
      smart00295
      Location:38 → 231
      B41; Band 4.1 homologues
      cd13193
      Location:218 → 339
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:954 → 1052
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:332 → 365
      FA; FERM adjacent (FA)
      cl02571
      Location:583 → 710
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:790 → 896
      PH-like; Pleckstrin homology-like domain

    2. NM_001375142.3 → NP_001361874.1  FERM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17905
      Conserved Domains (3) summary
      smart00295
      Location:26 → 219
      B41; Band 4.1 homologues
      cd13193
      Location:206 → 327
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      pfam08736
      Location:320 → 353
      FA; FERM adjacent (FA)

    3. NM_077534.3 → NP_509935.2  FYVE, RhoGEF and PH domain-containing protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509935.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDC0
      Conserved Domains (3) summary
      cd13235
      Location:536 → 634
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      cl02571
      Location:165 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:372 → 478
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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