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    Y57G11C.1147 Protein BRICK1 [ Caenorhabditis elegans ]

    Gene ID: 178404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y57G11C.1147
    Official Full Name
    Protein BRICK1
    Primary source
    WormBase:WBGene00303007
    Locus tag
    CELE_Y57G11C.1147
    See related
    AllianceGenome:WB:WBGene00303007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell motility and regulation of actin polymerization or depolymerization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of SCAR complex. Orthologous to human BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y57G11C.1147 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (14796442..14797514, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Rab GDP dissociation inhibitor Neighboring gene Ubiquinone biosynthesis O-methyltransferase, mitochondrial Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Neighboring gene ADP-ribosylation factor-like protein 8B Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Zou W, et al. Dev Cell, 2018 May 7. PMID 29738713, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCAR complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein BRICK1
    NP_001367161.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14796442..14797514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380539.2 → NP_001367161.1  Protein BRICK1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5Z2X2
      Conserved Domains (1) summary
      pfam10152
      Location:32 → 66
      CCDC53; Subunit CCDC53 of WASH complex
    Nucleotide Protein
    Heading Accession and Version

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