U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    stdh-1 Putative steroid dehydrogenase 1 [ Caenorhabditis elegans ]

    Gene ID: 182291, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    stdh-1
    Official Full Name
    Putative steroid dehydrogenase 1
    Primary source
    WormBase:WBGene00007363
    Locus tag
    CELE_C06B3.4
    See related
    AllianceGenome:WB:WBGene00007363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; intestine; muscle cell; nervous system; and tail. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See stdh-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (13906492..13908037)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Putative steroid dehydrogenase 3 Neighboring gene DUF3444 domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Bacterial vitamin B(12) production enhances nematode predatory behavior. Akduman N, et al. ISME J, 2020 Jun. PMID 32152389, Free PMC Article
    2. Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF-16/FOXO. Park S, et al. Aging Cell, 2021 Jan. PMID 33382195, Free PMC Article
    3. Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Yamawaki TM, et al. Genetics, 2008 Jan. PMID 18202391, Free PMC Article
    4. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. Hansen M, et al. PLoS Genet, 2008 Feb. PMID 18282106, Free PMC Article
    5. Hexosamine pathway metabolites enhance protein quality control and prolong life. Denzel MS, et al. Cell, 2014 Mar 13. PMID 24630720

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Putative steroid dehydrogenase 1
    NP_506449.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13906492..13908037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074048.4 → NP_506449.1  Putative steroid dehydrogenase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17703
      Conserved Domains (2) summary
      cd05356
      Location:47 → 289
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
      pfam00106
      Location:49 → 242
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17703.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools