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    tgt-1 Queuine tRNA-ribosyltransferase catalytic subunit [ Caenorhabditis elegans ]

    Gene ID: 178131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tgt-1
    Official Full Name
    Queuine tRNA-ribosyltransferase catalytic subunit
    Primary source
    WormBase:WBGene00006566
    Locus tag
    CELE_ZK829.6
    See related
    AllianceGenome:WB:WBGene00006566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA-guanosine(34) queuine transglycosylase activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be located in cytoplasm. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tgt-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (11957547..11959804, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glutamate dehydrogenase Neighboring gene ncRNA Neighboring gene Enoyl reductase (ER) domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nanoscale patterning of collagens in C. elegans apical extracellular matrix. Adams JRG, et al. Nat Commun, 2023 Nov 18. PMID 37980413, Free PMC Article
    2. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Queuine tRNA-ribosyltransferase catalytic subunit
    NP_502268.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11957547..11959804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069867.8 → NP_502268.2  Queuine tRNA-ribosyltransferase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23623
      Conserved Domains (1) summary
      cl19224
      Location:13 → 374
      TGT; Queuine tRNA-ribosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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