unc-5 Netrin receptor unc-5 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: unc-5
Official Full Name: Netrin receptor unc-5
Primary source: WormBase:WBGene00006745
Locus tag: CELE_B0273.4
See related: AllianceGenome:WB:WBGene00006745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; establishment or maintenance of actin cytoskeleton polarity; and regulation of neuron projection development. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Is expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Orthologous to several human genes including UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See unc-5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (5495664..5528338, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans.
Title: TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans.
We assume that in these mutants, secretion and stability of various TSR-containing and possibly other proteins are affected. Since impairment of UNC-5 alone is not sufficient for the development of the dumpy phenotype further C-mannosylation-dependent proteins must be involved.
Title: C-mannosylation supports folding and enhances stability of thrombospondin repeats.
abl-1 negatively regulates unc-53 during DTC migrations and requirement of unc-53 function during both AP and DV DTC migrations could be due to unc-53 mediated regulation of unc-5 activity
Title: The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.
Small GTPases mediate MOM-5's regulation of unc-5 such that one outcome of impaired function of small GTPases like CED-10/Rac and MIG-2/RhoG is an increase in unc-5 function.
Title: The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells.
The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.
Title: The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.
UNC-6/netrin, UNC-5 and UNC-40/DCC modulated the extent of growth cone protrusion. Loss-of-function unc-5 mutants displayed increased protrusion in repelled growth cones, whereas loss-of-function unc-6 or unc-40 mutants caused decreased protrusion.
Title: UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.
The enhancement of unc-5 caused by an sdn-1 mutation was rescued by expression of wild-type sdn-1 in the hypodermis or nervous system rather than the distal tip cell (DTC)
Title: SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans.
UNC-129, graded opposite to UNC-6/netrin, functions independent of the canonical TGF-beta receptors to regulate UNC-5 cellular responses
Title: UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
the axon guidance cue UNC-6/netrin and its receptor UNC-5 act throughout development to exclude synaptic vesicle and active zone proteins from the dendrite of the Caenorhabditis elegans motor neuron DA9, which is proximal to a source of UNC-6/netrin
Title: UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.
Unc5 requires both Ig domains to interact with netrin.
Title: Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

B0273.4 (e-PCR)
- UniSTS:317440

STS4-131 (e-PCR)
- UniSTS:242120

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables netrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemorepulsion of axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in commissural neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Netrin receptor unc-5

NP_001293749.1

Confirmed by transcript evidence

NP_001293751.1

Confirmed by transcript evidence

NP_001368390.1

Confirmed by transcript evidence

NP_001380156.1

Confirmed by transcript evidence

NP_500822.2

Confirmed by transcript evidence

NP_500823.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5495664..5528338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068422.6 → NP_500823.1 Netrin receptor unc-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500823.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q26261

Conserved Domains (5) summary

smart00209
Location:277 → 325

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:112 → 199

I-set; Immunoglobulin I-set domain

cd08781
Location:822 → 907

Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family

cl02517
Location:500 → 609

ZU5; ZU5 domain

cl11960
Location:117 → 199

Ig; Immunoglobulin domain
NM_001392311.1 → NP_001380156.1 Netrin receptor unc-5 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

smart00209
Location:169 → 217

TSP1; Thrombospondin type 1 repeats

cd08781
Location:714 → 799

Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family

cd00096
Location:20 → 24

Ig; Ig strand B [structural motif]

pfam13927
Location:8 → 77

Ig_3; Immunoglobulin domain

pfam17217
Location:557 → 677

UPA; UPA domain

cl02517
Location:392 → 501

ZU5; ZU5 domain
NM_001306820.3 → NP_001293749.1 Netrin receptor unc-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44171, Q26261, Q26262, Q7JPT6, Q7KPX0, V6CK86, V6CLG6, V6CLK6, V6CLL7

Conserved Domains (6) summary

smart00209
Location:305 → 353

TSP1; Thrombospondin type 1 repeats

cd08781
Location:850 → 935

Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family

pfam17217
Location:693 → 813

UPA; UPA domain

cd00096
Location:147 → 151

Ig; Ig strand A' [structural motif]

cl02517
Location:528 → 637

ZU5; ZU5 domain

cl11960
Location:140 → 227

Ig; Immunoglobulin domain
NM_001306822.3 → NP_001293751.1 Netrin receptor unc-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293751.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CLK6

Conserved Domains (4) summary

smart00209
Location:110 → 158

TSP1; Thrombospondin type 1 repeats

cd08781
Location:655 → 740

Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family

pfam17217
Location:498 → 618

UPA; UPA domain

cl02517
Location:333 → 442

ZU5; ZU5 domain
NM_001380233.1 → NP_001368390.1 Netrin receptor unc-5 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

smart00209
Location:15 → 63

TSP1; Thrombospondin type 1 repeats

cd08781
Location:560 → 645

Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family

pfam17217
Location:403 → 523

UPA; UPA domain

cl02517
Location:238 → 347

ZU5; ZU5 domain
NM_068421.6 → NP_500822.2 Netrin receptor unc-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500822.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q26261

Conserved Domains (4) summary

smart00209
Location:277 → 325

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:112 → 199

I-set; Immunoglobulin I-set domain

cl02517
Location:500 → 552

ZU5; ZU5 domain

cl11960
Location:117 → 199

Ig; Immunoglobulin domain