mab-3 Protein male abnormal 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mab-3
Official Full Name: Protein male abnormal 3
Primary source: WormBase:WBGene00003100
Locus tag: CELE_Y53C12B.5
See related: AllianceGenome:WB:WBGene00003100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including SMDVL; head neurons; intestine; ray neurons; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mab-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (9732137..9738035)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two C. elegans DM domain proteins, DMD-3 and MAB-3, function in late stages of male somatic gonad development.
Title: Two C. elegans DM domain proteins, DMD-3 and MAB-3, function in late stages of male somatic gonad development.
the C. elegans 44 bp enhancer from vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway
Title: A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.
MAB-3 regulates oxidative stress sensitivity by repressing transcription of ELT-2 target genes in the intestine.
Title: The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans.
mab-3 is suppressed by mutants of mes-2, mes-3, and mes-6.
Title: Polycomb group regulation of Hox gene expression in C. elegans.
mab-3 is suppressed by the mutants of mes-2, mes-3, and mes-6.
Title: Finally, worm polycomb-like genes meet Hox regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y53C12B.5a (e-PCR)
- UniSTS:320181

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein male abnormal 3

NP_001022464.1

Confirmed by transcript evidence

NP_001379328.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9732137..9738035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027293.2 → NP_001022464.1 Protein male abnormal 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022464.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18214, Q8I0Z0

Conserved Domains (1) summary

smart00301
Location:24 → 77

DM; Doublesex DNA-binding motif
NM_001393163.1 → NP_001379328.1 Protein male abnormal 3 [Caenorhabditis elegans]

Status: REVIEWED