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    msh-6 DNA mismatch repair protein [ Caenorhabditis elegans ]

    Gene ID: 171914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msh-6
    Official Full Name
    DNA mismatch repair protein
    Primary source
    WormBase:WBGene00003422
    Locus tag
    CELE_Y47G6A.11
    See related
    AllianceGenome:WB:WBGene00003422
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable four-way junction DNA binding activity and mismatched DNA binding activity. Involved in maintenance of DNA repeat elements and mismatch repair. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See msh-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (3449326..3462174)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CUB domain-containing protein Neighboring gene Separin homolog sep-1 Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Protein kinase domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene AFG3-like protein spg-7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Denver DR, et al. Genetics, 2005 May. PMID 15716493, Free PMC Article
    2. The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation. Denver DR, et al. Genetics, 2006 Sep. PMID 16783005, Free PMC Article
    3. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Tijsterman M, et al. Genetics, 2002 Jun. PMID 12072462, Free PMC Article
    4. Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans. Wynen F, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37730131
    5. A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death. Weidhaas JB, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16788064, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MMR surveillance is carried out by a single Msh-2/Msh-6 heterodimer
      Title: Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutSalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MutSalpha complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA mismatch repair protein
    NP_491163.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3449326..3462174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058762.6 → NP_491163.1  DNA mismatch repair protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3T8
      Conserved Domains (1) summary
      COG0249
      Location:251 → 1145
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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