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    dhs-8 SDR family NAD(P)-dependent oxidoreductase [ Caenorhabditis elegans ]

    Gene ID: 175108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-8
    Official Full Name
    SDR family NAD(P)-dependent oxidoreductase
    Primary source
    WormBase:WBGene00000972
    Locus tag
    CELE_K10H10.3
    See related
    AllianceGenome:WB:WBGene00000972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (14498026..14499755)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Bifunctional L-3-cyanoalanine synthase/cysteine synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AT rich interactive domain 1B (SWI1-like);Secreted protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SDR family NAD(P)-dependent oxidoreductase
    NP_001022250.1
    • Partially confirmed by transcript evidence
    NP_001293543.1
    • Confirmed by transcript evidence
    NP_001368222.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14498026..14499755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027079.3 → NP_001022250.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45680
      Conserved Domains (2) summary
      PRK06196
      Location:68 → 362
      PRK06196; oxidoreductase; Provisional
      cl21454
      Location:85 → 362
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001381658.1 → NP_001368222.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLQ0
      Conserved Domains (1) summary
      cl21454
      Location:27 → 304
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001306614.3 → NP_001293543.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB98
      Conserved Domains (1) summary
      cl21454
      Location:1 → 248
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_002361.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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