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    dnj-17 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-17
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001035
    Locus tag
    CELE_T03F6.2
    See related
    AllianceGenome:WB:WBGene00001035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in cytoplasm. Is expressed in head neurons and intestine. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-17 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (13390850..13393339, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Receptor expression-enhancing protein Neighboring gene F-box domain-containing protein Neighboring gene putative glucosamine-6-phosphate isomerase Neighboring gene Dihydropteridine reductase Neighboring gene DUF148 domain-containing protein;SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. Takayanagi-Kiya S, et al. G3 (Bethesda), 2016 Jul 7. PMID 27185401, Free PMC Article
    2. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altered function of the DNJ-17 modulates locomotor circuit activity in a Caenorhabditis elegans seizure model.
      Title: Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    J domain-containing protein
    NP_499759.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13390850..13393339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067358.6 → NP_499759.2  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62360
      Conserved Domains (4) summary
      COG5269
      Location:4 → 275
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      sd00020
      Location:293 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain
      pfam12171
      Location:292 → 315
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein
    Heading Accession and Version

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