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    pmp-2 Peroxisomal Membrane Protein related [ Caenorhabditis elegans ]

    Gene ID: 174127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pmp-2
    Official Full Name
    Peroxisomal Membrane Protein related
    Primary source
    WormBase:WBGene00004059
    Locus tag
    CELE_C44B7.9
    See related
    AllianceGenome:WB:WBGene00004059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in membrane and peroxisome. Predicted to be active in peroxisomal membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pmp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6884040..6887805, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acetyl-CoA hydrolase Neighboring gene Adenosine deaminase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: common features in eukaryotic organisms. Lee A, et al. Biochem Biophys Res Commun, 2014 Oct 24. PMID 25301552
    2. GATA transcription factor required for immunity to bacterial and fungal pathogens. Kerry S, et al. PLoS One, 2006 Dec 20. PMID 17183709, Free PMC Article
    3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
    4. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peroxisomal Membrane Protein related
    NP_495408.1
    • Product from WormBase gene class pmp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6884040..6887805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063007.5 → NP_495408.1  Peroxisomal Membrane Protein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18598
      Conserved Domains (3) summary
      cd03223
      Location:442 → 647
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:1 → 649
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:62 → 341
      ABC_membrane_2; ABC transporter transmembrane region 2
    Nucleotide Protein
    Heading Accession and Version

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