B0250.5 putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: B0250.5
Official Full Name: putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00007122
Locus tag: CELE_B0250.5
See related: AllianceGenome:WB:WBGene00007122
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See B0250.5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (20493924..20497345)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0250.5 (e-PCR)
- UniSTS:320192

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyisobutyrate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in branched-chain amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in valine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in valine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial

NP_001370011.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20493924..20497345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383509.2 → NP_001370011.1 putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTI0

Conserved Domains (1) summary

TIGR01692
Location:6 → 295

HIBADH; 3-hydroxyisobutyrate dehydrogenase