lin-11 Protein lin-11 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: lin-11
Official Full Name: Protein lin-11
Primary source: WormBase:WBGene00003000
Locus tag: CELE_ZC247.3
See related: AllianceGenome:WB:WBGene00003000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including axonal fasciculation; egg-laying behavior; and positive regulation of vulval development. Predicted to be active in nucleus. Is expressed in several structures, including B.pap; P5.p hermaphrodite; body wall musculature; egg-laying apparatus; and nervous system. Orthologous to several human genes including LHX1 (LIM homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See lin-11 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (10248288..10255327)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

neuronal expression of lin-11 involves multiple transcription factor regulators and regulatory modules some of which have diverged in Caenorhabditis nematodes.
Title: Intron-specific patterns of divergence of lin-11 regulatory function in the C. elegans nervous system.
multiple factors cooperate to regulate pi-specific expression of lin-11 and together with other findings suggest that the mechanism of lin-11 regulation by LIN-12/Notch signaling is evolutionarily conserved in Caenorhabditis species.
Title: Dissection of lin-11 enhancer regions in Caenorhabditis elegans and other nematodes.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZC247.3 (e-PCR)
- UniSTS:322454

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Protein lin-11

NP_492696.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10248288..10255327

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060295.6 → NP_492696.1 Protein lin-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492696.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20154

Conserved Domains (3) summary

cd09375
Location:127 → 182

LIM2_Lhx1_Lhx5; The second LIM domain of Lhx1 (also known as Lim1) and Lhx5

pfam00046
Location:244 → 297

Homeobox; Homeobox domain

pfam00412
Location:68 → 123

LIM; LIM domain