nhr-23 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-23
Official Full Name: Nuclear hormone receptor family member nhr-23
Primary source: WormBase:WBGene00003622
Locus tag: CELE_C01H6.5
See related: AllianceGenome:WB:WBGene00003622
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in chromatin and nucleus. Is expressed in several structures, including gonad; hypodermis; oocyte; spermatocyte; and vulva. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Orthologous to human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-23 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (7214745..7221299)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
Title: Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
Title: NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
Title: The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
these results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa.
Title: NHR-23 dependent collagen and hedgehog-related genes required for molting.
mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting.
Title: The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01H6.5 (e-PCR)
- UniSTS:307203

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in molting cycle, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-23

NP_001020975.1

Confirmed by transcript evidence

NP_001020977.1

Confirmed by transcript evidence

NP_001032969.1

Confirmed by transcript evidence

NP_001032971.1

Confirmed by transcript evidence

NP_001367012.1

Confirmed by transcript evidence

NP_001379448.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7214745..7221299

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025806.7 → NP_001020977.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41828

Conserved Domains (2) summary

cd06968
Location:5 → 99

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:233 → 429

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001037880.6 → NP_001032969.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001032969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41828

Conserved Domains (2) summary

cd06968
Location:5 → 99

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:235 → 431

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001025804.6 → NP_001020975.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020975.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41828, Q17380, Q17584, Q3S1J2, Q3S1J3, Q3S1J4, Q5FC60, Q9BJL3

Conserved Domains (2) summary

cd06968
Location:156 → 250

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:384 → 580

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001380645.2 → NP_001367012.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd06968
Location:121 → 215

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:349 → 545

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001037882.6 → NP_001032971.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001032971.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41828

Conserved Domains (2) summary

cd06968
Location:121 → 215

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:351 → 547

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001392520.1 → NP_001379448.1 Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cl02596
Location:1 → 23

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:157 → 353

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators