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    vps-20 Charged multivesicular body protein 6 [ Caenorhabditis elegans ]

    Gene ID: 171654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-20
    Official Full Name
    Charged multivesicular body protein 6
    Primary source
    WormBase:WBGene00022027
    Locus tag
    CELE_Y65B4A.3
    See related
    AllianceGenome:WB:WBGene00022027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (636804..637852)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA helicase Neighboring gene ncRNA Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene Cytidyltransferase-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Block S, et al. Methods Mol Biol, 2019. PMID 31250303, Free PMC Article
    2. Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments. Fyfe I, et al. J Biol Chem, 2011 Sep 30. PMID 21835927, Free PMC Article
    3. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. Schuh AL, et al. Biochem J, 2015 Mar 15. PMID 25588614, Free PMC Article
    4. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    5. Differential physiological roles of ESCRT complexes in Caenorhabditis elegans. Kim DW, et al. Mol Cells, 2011 Jun. PMID 21688204, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 6
    NP_490762.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      636804..637852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058361.7 → NP_490762.1  Charged multivesicular body protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL60
      Conserved Domains (1) summary
      pfam03357
      Location:23 → 184
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version

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