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    usp-50 ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 180175, updated on 27-Dec-2024

    Summary

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    Official Symbol
    usp-50
    Official Full Name
    ubiquitinyl hydrolase 1
    Primary source
    WormBase:WBGene00008441
    Locus tag
    CELE_E01B7.1
    See related
    AllianceGenome:WB:WBGene00008441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Predicted to be located in early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See usp-50 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (17924985..17934218)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cucumopine_C domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA-Gly Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Lysine-specific demethylase 9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV. Huynh JM, et al. Genetics, 2016 Feb. PMID 26596346, Free PMC Article
    2. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitinyl hydrolase 1
    NP_507513.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17924985..17934218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075112.8 → NP_507513.2  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507513.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBW2
      Conserved Domains (2) summary
      pfam00443
      Location:478 → 808
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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